Ferroptosis resistance mediated by exosomal release of iron
Ferroptosis resistance mediated by exosomal release of iron
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DOI：
10.1080/23723556.2020.1730144
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发表时间：
2020-03-23
影响因子：
2.1
通讯作者：
Mercurio, Arthur M.
中科院分区：
文献类型：
--
作者：
Brown, Caitlin W.;Mercurio, Arthur M.
了解细胞如何抵抗铁凋亡对于利用这种铁依赖性细胞死亡模式治疗癌症和其他疾病是必要的。我们发现，细胞通过启用PROMININ 2依赖性铁输出途径来抵抗铁凋亡，该途径涉及多泡体/外泌体将铁运输出细胞，减少铁凋亡所需的细胞内铁。
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.