Prolactin Secretion in Myotonic Dystrophy
Prolactin Secretion in Myotonic Dystrophy
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强直性肌营养不良中催乳素的分泌
DOI：
10.1055/s-0029-1211016
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
S. Todorovic
中科院分区：
文献类型：
--
作者：
Z. Marinković;G. Prelević;Rong Han;M. Würzburger;S. Todorovic
为了评价强直性肌营养不良（MD）女性的催乳素分泌，在13名强直性肌营养不良女性（10名正常催乳素血症和3名高催乳素血症）和8名健康女性中研究了TRH、甲氧氯普胺和溴隐亭对催乳素的反应。与对照组相比，TRH给药后，一组泌乳素正常的MD患者的平均最大净增加显著更高（p <0.05）。在3例基础催乳素水平升高的患者中，观察到对TRH的催乳素反应过度。在一组正常泌乳素血症和高泌乳素血症患者中，在胃复安推注后观察到正常泌乳素反应。溴隐亭给药后，泌乳素水平的最大净下降已被发现在正常泌乳素血症患者比健康受试者更大，虽然差异在统计学上是不显著的。溴隐亭的抑制作用在高催乳素血症患者中更为明显。这些结果表明，在强直性肌营养不良中，催乳素分泌存在一定的紊乱，导致某些患者的催乳素水平升高。虽然这种紊乱的机制尚未阐明，但似乎它不是通过多巴胺能受体介导的。
In order to evaluate prolactin secretion in females with myotonic dystrophy (MD) prolactin responses to TRH, metoclopramide and bromocriptine were studied in 13 women with myotonic dystrophy (10 normoprolactinaemic and 3 hyperprolactinaemic) and 8 healthy women. Following TRH administration mean maximal net increase was significantly higher in a group of normoprolactinaemic patients with MD in comparison to controls (p less than 0.05). In three patients with increased basal prolactin levels an exaggerated prolactin response to TRH has been observed. Normal prolactin response in a group of normoprolactinaemic as well as in hyperprolactinaemic patients have been observed following metoclopramide bolus injection. Following bromocriptine administration, maximal net decrease in prolactin levels has been found to be greater in normoprolactinaemic patients compared to healthy subjects, although the difference was statistically insignificant. The suppressive action of bromocriptine was more pronounced in patients with hyperprolactinaemia. Those results showed that there is some derangement in prolactin secretion in myotonic dystrophy leading to increased prolactin levels in some patients. Although the mechanism of this derangement has not been clarified yet it seems that it is not mediated via dopaminergic receptors.