Ambient Fine Particulate Matter, Nitrogen Dioxide, and Term Birth Weight in New York, New York
Ambient Fine Particulate Matter, Nitrogen Dioxide, and Term Birth Weight in New York, New York
复制标题
DOI：
10.1093/aje/kwt268
复制
发表时间：
2014-02-15
影响因子：
5
通讯作者：
Matte, Thomas D.
中科院分区：
文献类型：
--
作者：
Savitz, David A.;Bobb, Jennifer F.;Matte, Thomas D.
在纽约，纽约的一个独特的暴露评估项目的基础上，我们研究了空气动力学直径小于2.5米的颗粒物和二氧化氮与出生体重的关系，限制人口足月出生的非吸烟者，沿着其他限制，以隔离空气污染对生长的潜在影响。我们纳入了2008 - 2010年在生命记录中确定的252，967例出生，并通过使用考虑空间和时间因素的有效模型分配了居住地点的暴露。关联的估计进行了调整，个人和上下文的社会人口特征和季节，使用线性混合模型来量化的预测变化，在克出生体重与污染水平的增加。对空气动力学直径小于2.5 m的颗粒物的调整后估计值表明，暴露量每增加10 g/m3，妊娠早期、中期和晚期以及整个妊娠期的出生体重分别下降18.4、10.5、29.7和48.4 g。调整后的二氧化氮估计值表明，暴露量每增加10 ppb，出生体重分别下降14.2，15.9，18.0和18.0克的暴露在第一，第二和第三孕期和整个怀孕。这些结果有力地支持了城市空气污染暴露与胎儿生长减少的关联。
Building on a unique exposure assessment project in New York, New York, we examined the relationship of particulate matter with aerodynamic diameter less than 2.5 m and nitrogen dioxide with birth weight, restricting the population to term births to nonsmokers, along with other restrictions, to isolate the potential impact of air pollution on growth. We included 252,967 births in 20082010 identified in vital records, and we assigned exposure at the residential location by using validated models that accounted for spatial and temporal factors. Estimates of association were adjusted for individual and contextual sociodemographic characteristics and season, using linear mixed models to quantify the predicted change in birth weight in grams related to increasing pollution levels. Adjusted estimates for particulate matter with aerodynamic diameter less than 2.5 m indicated that for each 10-g/m(3) increase in exposure, birth weights declined by 18.4, 10.5, 29.7, and 48.4 g for exposures in the first, second, and third trimesters and for the total pregnancy, respectively. Adjusted estimates for nitrogen dioxide indicated that for each 10-ppb increase in exposure, birth weights declined by 14.2, 15.9, 18.0, and 18.0 g for exposures in the first, second, and third trimesters and for the total pregnancy, respectively. These results strongly support the association of urban air pollution exposure with reduced fetal growth.