Evidence for Improving Outcome Through Extent of Resection
Evidence for Improving Outcome Through Extent of Resection
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DOI：
10.1016/j.nec.2018.08.005
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发表时间：
2019-01-01
影响因子：
2.6
通讯作者：
Berger, Mitchel S.
中科院分区：
文献类型：
--
作者：
Hervey-Jumper, Shawn L.;Berger, Mitchel S.
手术切除在胶质瘤的治疗中起着核心作用，然而许多肿瘤位于区域内，导致感觉运动和认知后果。本文综述了支持切除范围以改善低级别胶质瘤存活率、症状管理和恶变时间的证据。根据WHO对低级别胶质瘤的分类，作者总结了有关最大限度安全切除的作用的不断发展的文献。胶质瘤切除后长期的神经功能障碍可能会阻碍患者的生存和生活质量。对胶质瘤相关中枢神经系统可塑性的新见解影响手术计划和干预时机。
Surgical resection plays a central role in the management of gliomas however many tumors are within areas resulting in sensorimotor and cognitive consequences. This article reviews the evidence in support of extent of resection to improve survival, symptom management, and time to malignant transformation in low-grade gliomas. The authors summarize the evolving literature regarding the role of maximal safe resection in light of WHO subclassification of low-grade gliomas. Long lasting neurological deficits following glioma resection may hinder both survival and quality of life. New insights into glioma related central nervous system plasticity impact both surgical planning and timing of interventions.