Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women
Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women
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DOI：
10.1210/jc.2003-031471
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Williams, NI
中科院分区：
文献类型：
--
作者：
Leidy, HJ;Gardner, JK;Williams, NI
Ghrelin直接参与能量平衡的短期调节。尽管神经性厌食症患者循环中生长素释放肽水平升高，肥胖患者循环中生长素释放肽水平降低，但生长素释放肽在健康女性中调节长期能量平衡的作用尚未研究。我们研究了3个月的能量缺乏强加的饮食和运动干预对正常体重的健康女性循环ghrelin的影响。在干预前、干预中和干预后，对不进行运动的对照组（n = 7）和保持体重稳定（n = 5）或体重减轻（n = 10）的运动女性的身体组成、静息代谢率和血清ghrelin进行了测量。运动训练每周进行五次，受试者被喂食特定的饮食。与对照组和体重稳定组相比，体重减轻组的Ghrelin随时间显著增加（770 +/- 296至1322 +/- 664 pmol/L）（P < 0.05）。Ghrelin的变化与体重变化呈负相关（r =-0.61; P < 0.05）。在饥饿素增加之前，减肥组的体脂、体重和静息代谢率显著降低。这些研究结果表明，生长激素释放肽以补偿的方式对健康年轻女性的能量稳态变化做出反应，并且生长激素释放肽对体重变化表现出特别的敏感性。
Ghrelin is directly involved with short-term regulation of energy balance. Although circulating levels of ghrelin are elevated in anorexia nervosa and reduced in obesity, the role of ghrelin in regulating long-term energy balance in healthy women has not been investigated. We examined the effects of a 3-month energy deficit-imposing diet and exercise intervention on circulating ghrelin in normal-weight, healthy women. Body composition, resting metabolic rate, and serum ghrelin were measured at pre-, mid-, and postintervention in controls (n = 7), who performed no exercise, and exercising women who remained weight stable ( n = 5) or lost weight ( n = 10). Exercise training occurred five times per week, and subjects were fed a specific diet. Ghrelin significantly increased over time ( 770 +/- 296 to 1322 +/- 664 pmol/liter) in the weight-loss group compared with the controls and the weight-stable group ( P < 0.05). Changes in ghrelin were negatively correlated with changes in body weight ( r = - 0.61; P < 0.05). Body fat, body weight, and resting metabolic rate significantly decreased in the weight-loss group before the increase in ghrelin. These findings suggest that ghrelin responds in a compensatory manner to changes in energy homeostasis in healthy young women, and that ghrelin exhibits particular sensitivity to changes in body weight.