Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.
Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.
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DOI：
10.1038/ncomms5991
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发表时间：
2014-09-26
影响因子：
16.6
通讯作者：
Lu, Q. Richard
中科院分区：
文献类型：
--
作者：
Shen, Yun-An A.;Chen, Yan;Dao, Dang Q.;Mayoral, Sonia R.;Wu, Laiman;Meijer, Dies;Ullian, Erik M.;Chan, Jonah R.;Lu, Q. Richard
The Schwann cell (SC)-axon interface represents a membrane specialization that integrates axonal signals to coordinate cytoskeletal dynamics resulting in myelination. Here we show that LKB1/Par-4 is asymmetrically localized to the SC-axon interface and colocalizes with the polarity protein Par-3. Using purified SCs and myelinating cocultures, we demonstrate that localization is dependent on the phosphorylation of LKB1 at serine-431. SC-specific deletion of LKB1 significantly attenuates developmental myelination, delaying the initiation and altering the myelin extent into adulthood, resulting in a 30% reduction in the conduction velocity along adult sciatic nerves. Phosphorylation of LKB1 by protein kinase A is essential to establish the asymmetric localization of LKB1 and Par-3 and rescues the delay in myelination observed in the SC-specific knockout of LKB1. Our findings suggest that SC polarity may coordinate multiple signaling complexes that couple SC-axon contact to the redistribution of specific membrane components necessary to initiate and control myelin extent.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1083/jcb.200705132
发表时间：
2007-08-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
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通讯作者：
Salzer JL