INFLUENCE OF ANGIOTENSIN-II TYPE-1 RECEPTOR POLYMORPHISM ON AORTIC STIFFNESS IN NEVER-TREATED HYPERTENSIVE PATIENTS
INFLUENCE OF ANGIOTENSIN-II TYPE-1 RECEPTOR POLYMORPHISM ON AORTIC STIFFNESS IN NEVER-TREATED HYPERTENSIVE PATIENTS
复制标题
DOI：
10.1161/01.hyp.26.1.44
复制
发表时间：
1995-07-01
期刊：
影响因子：
8.3
通讯作者：
CAMBIEN, F
中科院分区：
文献类型：
--
作者：
BENETOS, A;TOPOUCHIAN, J;CAMBIEN, F
一些临床和实验研究表明，血管紧张素II在小动脉和大动脉改变的发展中起着重要作用。本研究旨在评估血管紧张素II 1型受体（AT（1））基因多态性（对应于A（1166）-> C颠换）对主动脉僵硬度的贡献。134例从未接受过治疗的高血压患者被纳入研究。通过测量颈动脉-股动脉脉搏波速度评价主动脉扩张性。年龄、收缩压和舒张压以及代谢参数在三种基因型中相似。AT（1）AA纯合子的脉搏波速度为11.4+/-2.5 m/s，AC杂合子为12.5+/-3.2 m/s，CC纯合子为14.7+/-4.0 m/s（P=.003，P
Several clinical and experimental studies have suggested a significant role of angiotensin II in the development of alterations of small and large arteries. The present study was designed to assess the contribution of polymorphism (corresponding to an A(1166) --> C transversion) of the angiotensin II type 1 receptor (AT(1)) gene to aortic stiffness. One hundred thirty-four never-treated hypertensive patients were included in the study. Aortic distensibility was evaluated by measuring carotid-femoral pulse wave velocity. Age, systolic and diastolic pressure, and metabolic parameters were similar in the three genotypes. Pulse wave velocity was 11.4+/-2.5 m/s in AT(1) AA homozygotes, 12.5+/-3.2 m/s in AC heterozygotes, and 14.7+/-4.0 m/s in CC homozygotes (P=.003, P