Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains
Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains
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DOI：
10.1126/science.288.5475.2357
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发表时间：
2000-06-30
期刊：
影响因子：
56.9
通讯作者：
Taniguchi, T
中科院分区：
文献类型：
--
作者：
Takaoka, A;Mitani, Y;Taniguchi, T
对细胞因子的细胞应答的定义通常涉及通过其各自受体的交叉通信。在这里，通过干扰素-γ（IFN-γ）的信号传导显示出依赖于IFN-α/β受体组分。尽管这些IFN通过不同的受体复合物传递信号，但IFN-α/β受体组分IFNAR 1促进IFN-γ激活的转录因子的有效组装。这种串扰取决于组成性亚阈值IFN-α/β信号传导和两种非配体结合受体组分IFNAR 1和IFNGR 2在小窝膜结构域中的缔合。IFN的信号传导串扰的这一方面可能适用于其他细胞因子。
Definition of cellular responses to cytokines often involves cross-communication through their respective receptors. Here, signaling by interferon-gamma (IFN-gamma) is shown to depend on the IFN-alpha/beta receptor components. Although these IFNs transmit signals through distinct receptor complexes, the IFN-alpha/beta receptor component, IFNAR1, facilitates efficient assembly of IFN-gamma-activated transcription factors. This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. This aspect of signaling cross talk by IFNs may apply to other cytokines.