The ubiquitin-proteasome system meets angiogenesis.
The ubiquitin-proteasome system meets angiogenesis.
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DOI：
10.1158/1535-7163.mct-11-0555
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发表时间：
2012-03
影响因子：
5.7
通讯作者：
Rahimi N
中科院分区：
文献类型：
--
作者：
Rahimi N
内源性促血管生成因子和抗血管生成因子之间的严格生理平衡控制内皮细胞功能，使得内皮细胞生长通常受到抑制。然而，在病理性血管生成中，有利于内皮生长的调节因子的平衡发生了变化。许多血管生成事件的控制是通过缺氧诱导的VEGF表达来激发的。泛素-蛋白酶体系统在调节促血管生成核心蛋白VEGF、VEGFR-2、血管生成信号蛋白PLCγ1和PI 3激酶/AKT通路以及其他非VEGF血管生成通路的功能中起着核心作用。新出现的机制，其中泛素修饰的血管生成蛋白控制血管生成涉及蛋白水解和非蛋白水解功能。本文综述了泛素-蛋白酶体系统在血管生成调控中的最新研究进展，并重点介绍了泛素-蛋白酶体系统在血管生成相关疾病中的潜在治疗作用。
A strict physiological balance between endogenous pro-angiogenic and anti-angiogenic factors control endothelial cell functions, such that endothelial cell growth is normally restrained. However, in pathologic angiogenesis a shift occurs in the balance of regulators favoring endothelial growth. Much of control of angiogenic events is instigated through hypoxia-induced VEGF expression. Ubiquitin-proteasome system plays a central role in fine-tuning function of core pro-angiogenic proteins including VEGF, VEGFR-2, angiogenic signaling proteins including PLCγ1 and PI3 kinase/AKT pathway and other non-VEGF angiogenic pathways. The emerging mechanisms by which ubiquitin modification of angiogenic proteins control angiogenesis involve both proteolytic and non-proteolytic functions. Here, I review the recent advances linking ubiquitin-proteasome system to regulation of angiogenesis and highlights the potential therapeutic of ubiquitin-proteasome system in angiogenesis-associated diseases.