Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone.
Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone.
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温带栽培番石榴中具有稀有骨架的细胞毒性小萜类化合物
DOI：
10.1038/srep32748
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发表时间：
2016-09-02
影响因子：
4.6
通讯作者：
Liu HY
中科院分区：
文献类型：
--
作者：
Qin XJ;Yan H;Ni W;Yu MY;Khan A;Liu H;Zhang HX;He L;Hao XJ;Di YT;Liu HY
Three new meroterpenoids, guajavadials A–C (1–3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adducts of the 3,5-diformylbenzyl phloroglucinol and a sesquiterpene with different coupling models. The plausible biosynthetic pathways as well as antimicrobial and cytotoxic activities of these meroterpenoids are also discussed. All these isolates exhibited moderate cytotoxicities against five human cancer cell lines, with 3 being most effective with an IC50 value of 3.54 μM toward SMMC-7721 cell lines.
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影响因子：
5.1
作者：
Choi, Hyukjae;Hwang, Hoosang;Kang, Heonjoong
通讯作者：
Kang, Heonjoong
影响因子：
5.2
作者：
Tanaka, Naonobu;Abe, Shuhei;Kobayashi, Jun'ichi
通讯作者：
Kobayashi, Jun'ichi
影响因子：
4.7
作者：
Qin XJ;Zhao YL;Song CW;Wang B;Chen YY;Liu L;Li Q;Li D;Liu YP;Luo XD
通讯作者：
Luo XD
影响因子：
1.8
作者：
Mamemura, Takuji;Tanaka, Naonobu;Kobayashi, Jun'ichi
通讯作者：
Kobayashi, Jun'ichi
影响因子：
2.4
作者：
Ryu, Nae Hyung;Park, Kyung-Ran;Ahn, Kwang Seok
通讯作者：
Ahn, Kwang Seok