Oral Administration of Soy Peptides Suppresses Cognitive Decline by Induction of Neurotrophic Factors in SAMP8 Mice
Oral Administration of Soy Peptides Suppresses Cognitive Decline by Induction of Neurotrophic Factors in SAMP8 Mice
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DOI：
10.1021/jf405416s
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发表时间：
2014-04-23
影响因子：
6.1
通讯作者：
Nakamura, Soichiro
中科院分区：
文献类型：
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作者：
Katayama, Shigeru;Imai, Rie;Nakamura, Soichiro
SAMP8小鼠寿命较短，并表现出中枢神经系统功能障碍。我们在此研究了主要由二肽和三肽组成的大豆肽（SP）是否具有预防年龄依赖性认知障碍的潜力。 SAMP8 和正常衰老小鼠 SAMR1 被喂食添加 SP 的饮食或对照饮食 26 周，以使用莫里斯水迷宫研究对认知衰退进展的预防作用。与对照组相比，SAMP8 和 SAMR1 的 SP 喂养组阻止了认知能力的下降。在 SP 喂养的小鼠大脑中观察到 BDNF 和 NT-3 等神经营养因子的 mRNA 和蛋白质水平表达增加，尤其是 SAMP8。此外，SAMP8 的磷酸化 CREB 蛋白水平通过 SP 喂养显着上调。这些表明 SP 具有通过神经营养作用预防认知障碍的潜力。
SAMP8 mice have a shorter lifespan and show the dysfunction of the central nervous system. We here investigated whether soy peptides (SP) composed mainly of di- and tripeptides has the potential to prevent age-dependent cognitive impairment. SAMP8 and normal aging mice, SAMR1, were fed a diet supplemented with SP or a control diet for 26 weeks to investigate the preventive effects on the progression of cognitive decline using the Morris water maze. The SP-fed groups in SAMP8 and SAMR1 prevented the decline of cognitive ability compared to their controls. Increased expression of neurotrophic factors such as BDNF and NT-3 at mRNA and protein levels were observed in the brain of SP-fed mice, especially SAMP8. Further, the phosphorylated CREB protein level of SAMP8 was markedly up-regulated by SP feeding. These suggest that SPs have the potential for prevention of cognitive impairment via neurotrophic effects.