The gut-brain axis in obesity
The gut-brain axis in obesity
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DOI：
10.1016/j.bpg.2014.07.003
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发表时间：
2014-08-01
影响因子：
3.2
通讯作者：
Bueter, Marco
中科院分区：
文献类型：
--
作者：
Buhmann, Helena;le Roux, Care W.;Bueter, Marco
目前，唯一有效的治疗病态肥胖症的死亡率效益证明是手术干预。这些手术技术的潜在机制尚不清楚，但循环肠道激素水平的改变已被证明是至少一个促成因素。肠道激素似乎通过所谓的“肠-脑-轴”将信息从胃肠道传递到中枢神经系统（CNS）内的调节食欲中心。这种信息可以通过迷走神经或非迷走神经传入神经信号传导或直接通过血液循环传递到CNS。复杂的神经网络，分布在整个前脑和脑干，在控制进食和能量homoeostasis。本文旨在审查如何食欲是潜在的调节这些胃肠激素。确定食欲和体重控制的潜在机制可能为未来开发更好的手术技术和新疗法铺平道路。(C)2014爱思唯尔有限公司版权所有。
Currently the only effective treatment for morbid obesity with a proven mortality benefit is surgical intervention. The underlying mechanisms of these surgical techniques are unclear, but alterations in circulating gut hormone levels have been demonstrated to be at least one contributing factor. Gut hormones seem to communicate information from the gastrointestinal tract to the regulatory appetite centres within the central nervous system (CNS) via the so-called 'Gut-Brain-Axis'. Such information may be transferred to the CNS either via vagal or non-vagal afferent nerve signalling or directly via blood circulation. Complex neural networks, distributed throughout the forebrain and brainstem, are in control of feeding and energy homoeostasis.This article aims to review how appetite is potentially regulated by these gastrointestinal hormones. Identification of the underlying mechanisms of appetite and weight control may pave the way to develop better surgical techniques and new therapies in the future. (C) 2014 Elsevier Ltd. All rights reserved.