A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders.
A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders.
复制标题
DOI：
10.1089/cap.2011.0063
复制
发表时间：
2012-04
影响因子：
1.9
通讯作者：
K. Saxena;L. Tamm;A. Walley;A. Simmons;N. Rollins;J. Chia;J. Soares;G. Emslie;Xin Fan;Hao Huang
中科院分区：
文献类型：
--
作者：
K. Saxena;L. Tamm;A. Walley;A. Simmons;N. Rollins;J. Chia;J. Soares;G. Emslie;Xin Fan;Hao Huang
目的：虽然双相情感障碍（BPD）的行为缺陷已被很好地描述，但特异性脑白质（WM）破坏尚未完全表征，并且BPD功能障碍的神经机制尚未很好地确定，特别是对于患有BPD和攻击性的青少年。这项初步研究利用弥散张量成像（DTI）来研究青年BPD患者的联合束（胼胝体[CC]和前联合束[AC]），因为半球间交流的中断可能导致该疾病特征的情绪缺陷。方法采用DTI方法对10例BPD青年（7-17岁）和10例典型发展年龄相匹配的对照组进行WM调查。采用基于束的空间统计体素分析比较两组的分数各向异性（FA）。我们特别关注中矢状面CC的五个细分以及连接颞叶的AC的讨论。计算BPD组FA值与攻击行为生活史评分之间的探索性相关性。结果BPD青年胼胝体膝和AC的FA值显著降低，AC的FA值与BPD组的攻击生活史呈负相关。结论：这些结果有助于越来越多的文献表明CC的基因在BPD中起作用，并且首次报道了BPD患儿AC的WM变化。结合攻击和前皮层在情绪加工中的作用的相关数据，我们的数据为前皮层WM的结构完整性与儿童BPD攻击之间的可能关联提供了初步证据。
OBJECTIVE Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. METHOD DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. RESULTS Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. CONCLUSIONS These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.