Cannula Tip With Integrated Volume Sensor for Rotary Blood Pump Control: Early-Stage Development.
Cannula Tip With Integrated Volume Sensor for Rotary Blood Pump Control: Early-Stage Development.
复制标题
带有集成容量传感器的插管尖端，用于旋转血泵控制：早期开发。
DOI：
10.1097/mat.0000000000000818
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Rosenberg,Gerson
中科院分区：
文献类型：
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作者：
Cysyk,Joshua;Newswanger,Ray;Popjes,Eric;Pae,Walter;Jhun,Choon-Sik;Izer,Jenelle;Weiss,William;Rosenberg,Gerson
左心室卸载的直接测量的缺乏是一个显着的障碍，自动速度控制系统的连续流左心室辅助装置（cf-LVAD）的发展。我们已经开发了一种用于cf-LVAD的入口套管头端，其具有集成电极，用于基于电导的体积感测。将四个铂铱环电极安装到由聚醚醚酮（PEEK）制成的插管主体上的凹槽中。在一对电极上施加正弦电流激励波形（250 μA峰-峰，50 kHz），并在第二对电极上感测电导相关电压。在急性绵羊模型（n= 3）中测试了电导导管与HeartMate II旋转血泵的联合使用，以提供循环支持并卸载心室。在泵支持期间使用超声心动图测量心室大小，以验证电导测量值。从最小支持到抽吸的整个泵支持范围内，电导测量值与超声心动图尺寸测量值呈线性相关。该套管尖端将使自动控制系统的开发能够基于心室尺寸的实时测量来优化泵支持。
The lack of direct measurement of left ventricular unloading is a significant impediment to the development of an automatic speed control system for continuous-flow left ventricular assist devices (cf-LVADs). We have developed an inlet cannula tip for cf-LVADs with integrated electrodes for volume sensing based on conductance. Four platinum-iridium ring electrodes were installed into grooves on a cannula body constructed from polyetheretherketone (PEEK). A sinusoidal current excitation waveform (250 μA pk-pk, 50 kHz) was applied across one pair of electrodes, and the conductance-dependent voltage was sensed across the second pair of electrodes. The conductance catheter was tested in an acute ovine model (n= 3) in conjunction with the HeartMate II rotary blood pump to provide circulatory support and unload the ventricle. Echocardiography was used to measure ventricular size during pump support for verification for the conductance measurements. The conductance measurements correlated linearly with the echocardiography dimension measurements more than the full range of pump support from minimum support to suction. This cannula tip will enable the development of automatic control systems to optimize pump support based on a real-time measurement of ventricular size.