Identification and quantitation of diketopiperazines by liquid chromatography—mass spectrometry, using a moving belt interface
Identification and quantitation of diketopiperazines by liquid chromatography—mass spectrometry, using a moving belt interface
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DOI：
10.1016/s0021-9673(01)94161-5
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发表时间：
1987
影响因子：
4.1
通讯作者：
J. Greef;A. Tas;L. Nijssen;J. Jetten;M. Höhn
中科院分区：
文献类型：
--
作者：
J. Greef;A. Tas;L. Nijssen;J. Jetten;M. Höhn
采用高效液相色谱-质谱联用技术，采用移动带接口，对可可粉中的哌嗪二酮进行了快速分析。在线高分辨率测量用于鉴定可可粉提取物中的环（-Pro-Leu）、环（-Pro-Gly）、环（-Pro-Phe）、环（-Val-Phe）、环（-Gly-Phe）、环（-Ala-Val）、环（-Ala-Gly）、环（-Ala-Phe）、环（-Asn-Pro）和环（-Ala-Pro）。已经获得了吡咯烷酮和在吡咯烷环中具有双键的二酮哌嗪环（-Ala-Pro）的存在的证据。
High-performance liquid chromatography in combination with mass spectrometry using a moving belt interface was applied to rapid profiling of diketopiperazines in cocoa powder. On-line high resolution measurements were used for the identification of Cyclo(-Pro-Leu), Cyclo(-Pro-Gly), Cyclo(-Pro-Phe), Cyclo(-Val-Phe), Cyclo(-Gly-Phe), Cyclo(-Ala-Val), Cyclo(-Ala-Gly), Cyclo(-Ala-Phe), Cyclo(-Asn-Pro) and Cyclo(-Ala-Pro) in cocoa powder extracts. Evidence for the presence of pyrrolidone and a diketopiperazine Cyclo(-Ala-Pro) with a double bond in the pyrrolidine ring has been obtained.