Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation
Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation
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钽纳米颗粒增强聚醚醚酮显示出增强的骨形成
DOI：
10.1016/j.msec.2019.03.091
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xiao Jun
中科院分区：
文献类型：
--
作者：
Zhu Hao;Ji Xiongfa;Guan Hanfeng;Zhao Liming;Zhao Libo;Liu Changyu;Cai Cong;Li Weijing;Tao Tenghui;Resel;Janne Min;Haugen Havard Jostein;Xiao Jun
聚醚醚酮（PEEK）在骨科手术中已经使用了几十年。人们发明了许多方法来改变PEEK的性能。通过添加纳米粒子、纤维等。， PEEK的弹性模量和强度可以改变以满足一定的需求。在这项研究中，钽（Ta），一种很有前途的金属，被引入来修饰PEEK的性能，在PEEK中添加不同含量的钽纳米颗粒（从1 wt%到9 wt%）。然后研究了机械性能和生物功能（体外和体内）。3%Ta-PEEK的弹性模量和抗压强度最高。细胞粘附、胶原分泌、生物矿化和成骨相关基因表达实验结果表明，3%和5%的ta - peek效果较好。3%Ta-PEEK和5% ta - peek在体内可改善骨整合。综上所述，与其他组相比，3%Ta-PEEK和5%Ta-PEEK的力学性能得到了增强，骨形成得到了促进，这表明纳米钽颗粒的加入改变了PEEK的骨整合能力。这种钽和PEEK的复合材料在骨科植入物方面具有临床应用潜力。
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers,etc., elastic modulus and strength of PEEK can be changed to meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced to modify the properties of PEEK, in which PEEK was reinforced with different contents of tantalum nanoparticles (from 1 wt% to 9 wt%). Mechanical properties and biological functions (bothin vitroandin vivo) were then investigated. The highest elastic modulus and compressive strength were observed in 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization and osteogenesis related gene expression showed preferable results in 3%Ta-PEEK and 5%Ta-PEEK. Improved bone integration was shown in 3%Ta-PEEK and 5%Ta-PEEKin vivo. Above all, enhanced mechanical properties and promoted bone formation were proved for 3%Ta-PEEK and 5%Ta-PEEK compared to others groups bothin vitroandin vivo, suggesting that the addition of tantalum nanoparticles modified the osseointegration ability of PEEK. This composite of tantalum and PEEK could have a clinical potential for orthopedic implants.