Reduced cold pain tolerance in chronic pain patients following opioid detoxification.
Reduced cold pain tolerance in chronic pain patients following opioid detoxification.
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阿片类药物解毒后慢性疼痛患者的冷痛耐受性降低。
DOI：
10.1111/j.1526-4637.2008.00475.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Mackey,Sean
中科院分区：
文献类型：
--
作者：
Younger,Jarred;Barelka,Peter;Carroll,Ian;Kaplan,Kim;Chu,Larry;Prasad,Ravi;Gaeta,Ray;Mackey,Sean
Objective.One potential consequence of chronic opioid analgesic administration is a paradoxical increase of pain sensitivity over time. Little scientific attention has been given to how cessation of opioid medication affects the hyperalgesic state. In this study, we examined the effects of opioid tapering on pain sensitivity in chronic pain patients.Design.Twelve chronic pain patients on long-term opioid analgesic treatment were observed in a 7- to 14-day inpatient pain rehabilitation program, with cold pain tolerance assessed at admission and discharge. The majority of participants were completely withdrawn from their opioids during their stay.Outcome Measures.We hypothesized that those patients with the greatest reduction in daily opioid use would show the greatest increases in pain tolerance, as assessed by a cold pressor task.Results.A linear regression revealed that the amount of opioid medication withdrawn was a significant predictor of pain tolerance changes, but not in the direction hypothesized. Greater opioid reduction was associated with decreased pain tolerance. This reduction of pain tolerance was not associated with opioid withdrawal symptoms or changes in general pain.Conclusions.These findings suggest that the withdrawal of opioids in a chronic pain sample leads to an acute increase in pain sensitivity.
