Characterization of behavioural responses in different test contexts after a single social defeat in male golden hamsters (Mesocricetus auratus)
Characterization of behavioural responses in different test contexts after a single social defeat in male golden hamsters (Mesocricetus auratus)
复制标题
DOI：
10.1016/j.beproc.2010.10.005
复制
发表时间：
2011-01-01
影响因子：
1.3
通讯作者：
Lai, Wen-Sung
中科院分区：
文献类型：
--
作者：
Huang, Ching-Hsun;Kuo, Ming-Tsung;Lai, Wen-Sung
本研究的目的是描述雄性仓鼠在经历过一次社交失败或中性遭遇后，在三种测试环境中的行为反应。在实验1中，在熟悉的社会环境中观察仓鼠（即，他们的家笼子），和失败的男性表现出不同的时间和顺从行为对一个已知的对手比一个新的入侵者，而男性在中立的遭遇组没有表现出这种差异。在实验2中，在一个不熟悉的社会背景下（即，一个Y-迷宫），失败的男性产生顺从行为和恐惧记忆对一个已知的对手，他们再次遇到失败后5分钟和24小时。通过注射茴香霉素（210 mg/kg）中断长期记忆的形成。在实验3中，在一个非社会性的，焦虑的背景下，仓鼠，以前有不同的社会经验没有表现出额外的焦虑，在高架十字迷宫，与男性，以前经历过反复的社会失败的例外。我们的数据表明，仓鼠失败后的行为变化是依赖于环境和刺激特异性的。一次社交失败的经历足以让人在再次遇到已知对手时重新产生顺从行为和恐惧记忆。(C)2010 Elsevier B. V.保留所有权利。
The objective of the present study was to characterize behavioural responses of male hamsters in each of three test contexts after they had experienced either a single social defeat or a neutral encounter. In experiment 1, hamsters were observed in a familiar social context (i.e., their home cages), and defeated males displayed different amounts of time and submissive behaviours towards a known opponent than a novel intruder, whereas males in the neutral-encounter groups did not show such differences. In experiment 2, in an unfamiliar social context (i.e., a Y-maze), defeated males generated submissive behaviours and fear memory towards a known opponent that they re-encountered 5-min and 24-h after the defeat. The formation of long-term memory was interrupted by an injection of anisomycin (210 mg/kg). In experiment 3, in a non-social, anxiogenic context, hamsters that had previously had different social experiences did not demonstrate additional anxiety in an elevated plus-maze, with the exception of males that had previously experienced repeated social defeats. Our data suggested that hamsters' behavioural changes following defeat are context-dependent and stimulus-specific. The experience of a single social defeat is sufficient to regenerate submissive behaviours and fear memory when reencountering a known opponent. (C) 2010 Elsevier B.V. All rights reserved.