Pharmacokinetics of Photofrin II distribution in man
Pharmacokinetics of Photofrin II distribution in man
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Photofrin II 在人体中分布的药代动力学
DOI：
10.1117/12.44057
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发表时间：
1991
影响因子：
2.2
通讯作者：
E. Sykes
中科院分区：
文献类型：
--
作者：
D. Kessel;U. Nseyo;V. Schulz;E. Sykes
在给予Photofrin II（2 mg/kg）后，每隔一段时间从4名患者中采集血浆样品。水解后估计血浆和蛋白质/脂蛋白级分中的总卟啉，并通过HPLC测量不同Photofrin II组分的水平。提供了与血浆中总卟啉的损失率以及与白蛋白和脂蛋白组分结合的致敏剂的合并量和半衰期相关的药代动力学数据。观察到Photofrin II的最疏水组分的优先持久性。
Plasma samples were obtained from 4 patients at intervals after administration of Photofrin II (2 mg/kg). Total porphyrin in plasma and protein/lipoprotein fractions was estimated after hydrolysis, and levels of different Photofrin II components were measured by HPLC. Pharmacokinetic data are provided relating to rates of loss of total porphyrin from plasma and to pool size and half-lives of sensitizers bound to albumin and lipoprotein fractions. Preferential persistence of the most hydrophobic components of Photofrin II was observed.
影响因子：
9.7
作者：
KESSEL, D
通讯作者：
KESSEL, D