Ankylosis of permanent first molars: Genetics or environment? A case report of a discordant twin pair
Ankylosis of permanent first molars: Genetics or environment? A case report of a discordant twin pair
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DOI：
10.1016/j.ortho.2010.12.007
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发表时间：
2011-03-01
影响因子：
1.5
通讯作者：
Cohen-Levy, Julia
中科院分区：
文献类型：
--
作者：
Cohen-Levy, Julia
文献中报道了继发性尿潴留的罕见情况，认为是遗传性的，一些作者认为是常染色体显性遗传。我们报告了一个不寻常的情况下，两个单卵双羊膜，双绒毛膜男性双胞胎，谁是不和谐的永久第一磨牙继发保留，涉及强直。双胞胎A显示正常咬合和萌出模式，而双胞胎B显示左开牙合，与完全浸没的乳第二磨牙相关，导致下方前磨牙保持（35），以及相邻恒磨牙严重咬合不足（36）。正畸失败后，关闭开咬，36强直被证实，而26成为严重的低咬合。母亲有双侧磨牙强直病史，后牙槽高度降低。这对双胞胎的不一致性表明，除了表观遗传和局部因素外，环境影响可能在继发性保留中发挥作用，这是难以诊断和治疗的挑战。由Elsevier Masson SAS出版。版权所有
The rare condition of secondary retention has been reported in the literature as being of genetic origin, with some authors suggesting an autosomal dominant pattern. We report the unusual case of two monozygotic biamniotic, bichorionic male twins, who were discordant for permanent first molar secondary retention, involving ankylosis. Twin A showed normal occlusion and eruption patterns, whereas Twin B displayed a left open bite, in relation with a totally submerged primary second molar leading to retention of the underlying premolar (35), and severe infraocclusion of the adjacent permanent molar (36). After orthodontic failure to close the open bite, ankylosis of 36 was confirmed, whereas 26 became severely infraoccluded. The mother had a history of bilateral molar ankylosis and presented reduced posterior alveolar height. Discordance in this twin pair demonstrates that environmental influences, in addition to epigenetic and local factors, may play a role in secondary retention, which is difficult to diagnose and challenging to treat. (C) 2011 CEO. Published by Elsevier Masson SAS. All rights reserved