Microvessel density as a prognostic factor in esophageal squamous cell cancer patients: A meta-analysis.
Microvessel density as a prognostic factor in esophageal squamous cell cancer patients: A meta-analysis.
复制标题
微血管密度作为食管鳞状细胞癌患者预后因素的荟萃分析
DOI：
10.1097/md.0000000000007600
复制
发表时间：
2017-07
期刊：
影响因子：
1.6
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Ma G;Zhang J;Jiang H;Zhang N;Zhu Y;Deng Y;Zhou Q
到目前为止，文献已经出现，显示相互矛盾的结果，微血管密度（MVD）在食管鳞状细胞癌（ESCC）的预后作用。本研究旨在探讨食管鳞癌组织中微血管密度与预后的关系。从各种数据库中获得并审查了已识别的出版物。我们进行了一项荟萃分析，以评估MVD在ESCC患者中的预后作用。共有11项合格的研究（包含891例ESCC病例）被纳入荟萃分析。总生存率的合并风险比为2.39（95%置信区间1.92-2.96，P <0.001）。 研究间异质性不显著，未发现发表偏倚，还对不同问题进行了亚组分析，如地区、抗体和中位年龄。高MVD是食管鳞癌的一个预后因素，提示这些患者预后较差。还需要更多的研究，通过大量的证据，到那时可以重新评估这个话题。
To date, literature has emerged that shows contradictory results about the prognostic role of microvessel density (MVD) in esophageal squamous cell cancer (ESCC). The aim of the study set out to evaluate the correlation between MVD and the prognosis of ESCC. Identified publications from various databases were obtained and reviewed. A meta-analysis was performed to evaluate the prognostic role of MVD among ESCC patients. A total of 11 eligible studies containing 891 ESCC cases were included in the meta-analysis. The pooled hazard ratio for overall survival was 2.39 (95% confidence interval 1.92–2.96, P < .001). Heterogeneity among the studies was not significant, and publication bias was not found. Subgroup analyses were also performed on different issues, such as districts, antibodies, and median age. High MVD is a prognostic factor among ESCC that indicated worse prognosis in these patients. More studies are needed, and through abundant evidence, the topic could be re-evaluated by then.