Signalling and autophagy regulation in health, aging and disease
Signalling and autophagy regulation in health, aging and disease
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DOI：
10.1016/j.mam.2006.08.002
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发表时间：
2006-10-01
影响因子：
10.6
通讯作者：
Codogno, Patrice
中科院分区：
文献类型：
--
作者：
Meijer, Alfred J.;Codogno, Patrice
近年来，我们已经清楚地认识到，自噬不仅可以产生用于蛋白质合成的氨基酸，也可以在细胞饥饿时产生用于能量生产的底物，而且自噬还能够消除有缺陷的细胞结构，因此该过程可能与几种疾病状态有关。自噬由复杂的信号通路控制，包括胰岛素使用的信号通路。在这些途径中，磷脂酰肌醇3-激酶和蛋白激酶mTOR发挥重要作用。(c) 2006 Elsevier Ltd.版权所有。
It has become clear in recent years that autophagy not only serves to produce amino acids for ongoing protein synthesis and to produce substrates for energy production when cells become starved but autophagy is also able to eliminate defective cell structures and for this reason the process may be implicated in several diseased states. Autophagy is controlled by complex signalling pathways, including that used by insulin. In these pathways, phosphatidylinositol 3-kinases and the protein kinase mTOR play important roles. (c) 2006 Elsevier Ltd. All rights reserved.