Tunneling-nanotube direction determination in neurons and astrocytes.
Tunneling-nanotube direction determination in neurons and astrocytes.
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神经元和星形胶质细胞中的隧道纳米管方向确定
DOI：
10.1038/cddis.2012.177
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发表时间：
2012-12-06
影响因子：
9
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中科院分区：
文献类型：
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隧道纳米管（TNT）是一种新发现的涉及细胞间通讯的结构，存在于各种细胞中。在这里，我们确定S100 A4作为一种细胞外分子，并描述其在吸引的生长方向的TNT的作用。连同其推定的受体，受体的晚期糖基化终产物，我们证明他们参与TNT方向的指导。我们的研究结果进一步提出了一个机制，方向指导的TNT。在TNT起始细胞中，p53激活caspase-3，导致S100 A4裂解及其随后的细胞浓度降低。细胞S100 A4的减少诱导形成S100 A4的梯度，从起始细胞中的低浓度到靶细胞中的高浓度。S100 A4的这种浓度梯度诱导了对TNT的方向引导。
A tunneling nanotube (TNT) is a newly discovered structure involved in cell–cell communication and is found in various types of cells. Here we identify S100A4 as an extracellular molecule and describe its role in attracting the growth direction of TNTs. Together with its putative receptor, receptor for advanced glycation end product, we demonstrate their involvement in TNT direction guidance. Our results further suggest a mechanism for direction guidance of TNTs. In TNT-initiating cells, p53 activates caspase-3, which leads to S100A4 cleavage and its subsequent decrease in cellular concentration. The decrease in cellular S100A4 induces the formation of a gradient of S100A4, from a low concentration in initiating cells toward a high concentration in target cells. This concentration gradient of S100A4 induces direction guidance for TNTs.