Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men.
Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men.
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DOI：
10.1371/journal.pone.0153619
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Ouchi N
中科院分区：
文献类型：
--
作者：
Hayakawa S;Ohashi K;Shibata R;Takahashi R;Otaka N;Ogawa H;Ito M;Kanemura N;Hiramatsu-Ito M;Ikeda N;Murohara T;Ouchi N
卵泡抑素样蛋白1(FSTL1)是一种循环糖蛋白，在心血管疾病和炎症相关疾病中发挥重要作用。我们已经证明，FSTL1是一种抗炎因子，可以预防缺血性心脏病和慢性肾脏疾病。在这里，我们研究了表面健康的日本男性的血浆FSTL1水平是否与炎症和氧化应激的标志物相关。采用双抗体夹心酶联免疫吸附试验检测血浆FSTL1水平。循环FSTL1浓度与空腹免疫反应性胰岛素(FIRI)、高敏C反应蛋白(HsCRP)和氧化应激指标反应性氧化代谢产物(DROMs)的水平呈正相关。HsCRP水平与FSTL1、体重指数(BMI)、甘油三酯、FIRI和DROMS水平呈正相关。DROMS水平与FSTL1、HbA1c、hsCRP水平呈正相关。有混杂因素的多元回归分析显示，FSTL1水平、BMI和FIRI与hsCRP相关，FSTL1水平与DROMS相关。我们的观察表明，血浆FSTL1水平的测量对于评估促炎和氧化应激状态是有价值的。
Follistatin-like 1 (Fstl1) is a circulating glycoprotein that plays a crucial role in cardiovascular diseases and inflammation-related disorders. We have shown that Fstl1 acts as an anti-inflammatory factor that protects against ischemic heart disease and chronic kidney disease. Here we examined whether plasma level of Fstl1 associates with markers of inflammation and oxidative stress in apparently healthy Japanese men. Plasma Fstl1 levels were measured by enzyme-linked immunosorbent assay. Circulating Fstl1 concentrations positively correlated with levels of fasting immune-reactive insulin (FIRI), high-sensitive CRP (hsCRP) and derivatives of reactive oxidative metabolites (dROMs), an indicator of oxidative stress. The levels of hsCRP positively associated with Fstl1, body mass index (BMI), triglyceride, FIRI and dROMs levels. dROMs levels positively associated with Fstl1, Hemoglobin A1c and hsCRP levels. Multiple regression analysis with confounding factors revealed that Fstl1 levels, together with BMI and FIRI, correlated with hsCRP and that Fstl1 levels correlated with dROMs. Our observations indicate that measurement of plasma Fstl1 levels can be valuable for assessment of pro-inflammatory and oxidative stress conditions.