Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
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DOI：
10.1086/651135
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发表时间：
2010-04-01
影响因子：
6.4
通讯作者：
Touqui, Lhousseine
中科院分区：
文献类型：
--
作者：
Debarbieux, Laurent;Leduc, Dominique;Touqui, Lhousseine
抗生素耐药细菌威胁着全世界的生命。虽然新的抗生素很稀缺，但使用噬菌体（感染细菌的病毒）很少被提议作为弥补这种短缺的手段。尽管最近取得了令人鼓舞的结果，但对噬菌体疗法的疗效仍然普遍存在疑问。使用生物发光的铜绿假单胞菌菌株，我们监测和量化了噬菌体治疗小鼠急性肺部感染的疗效。噬菌体治疗不仅能有效地挽救动物免于致死性感染，而且在细菌感染前24小时给予时也能够预防肺部感染，从而扩展了噬菌体作为治疗剂对抗细菌性肺部感染的潜在用途。
Antibiotic-resistant bacteria threaten life worldwide. Although new antibiotics are scarce, the use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of offsetting this shortage. Doubt also remains widespread about the efficacy of phage therapy despite recent encouraging results. Using a bioluminescent Pseudomonas aeruginosa strain, we monitored and quantified the efficacy of a bacteriophage treatment in mice during acute lung infection. Bacteriophage treatment not only was effective in saving animals from lethal infection, but also was able to prevent lung infection when given 24 h before bacterial infection, thereby extending the potential use of bacteriophages as therapeutic agents to combat bacterial lung infection.