Fluorophore and Dye-Assisted Dispersion of Carbon Nanotubes in Aqueous Solution
Fluorophore and Dye-Assisted Dispersion of Carbon Nanotubes in Aqueous Solution
复制标题
DOI：
10.1021/la302004p
复制
发表时间：
2012-08-14
期刊：
影响因子：
3.9
通讯作者：
Cheng, Wei
中科院分区：
文献类型：
--
作者：
Koh, Byumseok;Kim, Gwangseong;Cheng, Wei
DNA短寡聚物、表面活性剂、多肽和聚合物辅助的单壁碳纳米管（SWCNTs）在水溶液中的分散已经得到了深入的研究。研究表明，范德华相互作用、pi-pi堆叠和疏水相互作用是SWCNTs分散的主要因素。荧光团和染料分子如罗丹明B和荧光素具有亲水性和疏水性两个部分。这些分子还含有π共轭系统，可潜在地与SWCNTs相互作用以诱导其分散。通过系统的研究，我们发现SWCNTs可以分散在各种荧光团或染料分子存在的水溶液中。然而，荧光团或染料分子分散SWCNTs的能力与荧光团/染料- SWCNTs复合物的稳定性无关，这表明荧光团/染料与SWCNTs的结合率可能主导了该过程的效率。我们还研究了哺乳动物细胞在这些分子与SWCNTs形成复合物时对荧光团分子的摄取情况。该结果在递送细胞穿透性差的荧光团分子方面具有潜在的应用价值。
DNA short oligo, surfactant, peptides, and polymer-assisted dispersion of single-walled carbon nanotube (SWCNTs) in aqueous solution have been intensively studied. It has been suggested that van der Waals interaction, pi-pi stacking, and hydrophobic interaction are major factors that account for the SWCNTs dispersion. Fluorophore and dye molecules such as Rhodamine B and fluorescein have both hydrophilic and hydrophobic moieties. These molecules also contain pi-conjugated systems that can potentially interact with SWCNTs to induce its dispersion. Through a systematic study, here we show that SWCNTs can be dispersed in aqueous solution in the presence of various fluorophore or dye molecules. However, the ability of a fluorophore or dye molecule to disperse SWCNTs is not correlated with the stability of the fluorophore/dye-SWCNT complex, suggesting that the on-rate of fluorophore/dye binding to SWCNTs may dominate the efficiency of this process. We also examined the uptake of fluorophore molecules by mammalian cells when these molecules formed complexes with SWCNTs. The results can have potential applications in the delivery of poor cell-penetrating fluorophore molecules.