Sugar-assisted ligation for the synthesis of glycopeptides
Sugar-assisted ligation for the synthesis of glycopeptides
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DOI：
10.1002/chem.200700330
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发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Wong, Chi-Huey
中科院分区：
文献类型：
--
作者：
Brik, Ashraf;Wong, Chi-Huey
从易得的材料中化学合成糖蛋白是一种获得完全控制其原子结构的纯产品的有效方法。糖辅助连接(SAL)是一种新兴的方法，它允许从两个不受保护的片段合成一个大的糖肽。与其他仅限于使用半胱氨酸残基或依赖外部辅助的连接方法相反，SAL利用糖肽中现有的糖来促进两个肽之间的接近，以促进酰胺键的形成。
Chemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar-assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.