Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure
Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure
复制标题
具有机械梯度结构的喷墨印刷神经电极
DOI：
10.1021/acsabm.8b00574
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发表时间：
2018
影响因子：
4.7
通讯作者：
Fujie Toshinori
中科院分区：
文献类型：
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作者：
Kokubo Nana;Arake Masashi;Yamagishi Kento;Morimoto Yuji;Takeoka Shinji;Ohta Hiroyuki;Fujie Toshinori
柔性材料对于神经探针在体内记录稳定信号（峰值）的发展是重要的。在这里，我们提出了喷墨打印的，柔性的神经探针，用于用聚合物薄膜记录峰值。神经探针由400纳米厚的聚（d，l-乳酸）纳米膜、由金和聚（3,4-乙烯二氧噻吩）、聚苯磺酸纳米油墨、含氟聚合物层组成的喷墨打印线组成。用剃刀切割边缘，露出微电极。将厚度为6 μm的探针以厚度相关的方式逐渐增加刚度连接到外部放大器上。探针被制成针状，记录小鼠体内丘脑蛋白酶的峰值。
Flexible materials are important for the development of neural probes in recording stable signals (spikes)in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamusin vivo.