Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis
Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis
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唾液lncRNA作为口腔鳞状细胞癌诊断的潜在标志物
DOI：
10.3892/mmr.2012.1254
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发表时间：
2013-03-01
影响因子：
3.4
通讯作者：
Su, Bing
中科院分区：
文献类型：
--
作者：
Tang, Haikuo;Wu, Zhiyuan;Su, Bing
口腔鳞状细胞癌（OSCC）是一种常见且致命的恶性肿瘤。因此，迫切需要提高当前与 OSCC 相关的分子变化的知识，以探索该疾病的诊断和治疗的新途径。虽然长非编码 RNA (lncRNA) 的异常表达与某些类型的癌症（包括肺癌、乳腺癌和前列腺癌）存在功能相关性，但它们在 OSCC 中的表达模式和生物学相关性目前尚不清楚。在本研究中，研究了 OSCC 患者组织或唾液样本中 lncRNA 集合的相对丰度。结果表明，lncRNA 子集在非肿瘤、肿瘤和转移组织样本中表达。一些检测到的 lncRNA 在口腔癌和转移病例中表现出异常表达。此外，整个唾液中含有可检测量的一些 lncRNA，这似乎是 OSCC 的潜在标志物。这些发现表明唾液中lncRNA的检测可作为口腔癌诊断的无创快速诊断工具。
Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus, improvement in current knowledge of molecular changes associated with OSCC is urgently needed to explore novel avenues of diagnostics and treatment of this disease. While aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with certain types of cancer, including lung, breast and prostate carcinomas, their expression pattern and biological relevance in OSCC is currently unknown. In the present study, the relative abundance of a collection of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It was shown that subsets of lncRNAs are expressed across non-tumor, tumor and metastatic tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable amount of some lncRNAs, which appeared to be potential markers for OSCC. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.