The role of vitamins A, beta-carotene, E and C in cancer cell biology.
The role of vitamins A, beta-carotene, E and C in cancer cell biology.
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维生素 A、β-胡萝卜素、E 和 C 在癌细胞生物学中的作用。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
A. Lupulescu
中科院分区：
文献类型：
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作者：
A. Lupulescu
维生素A（视黄醇，类维生素A），β-胡萝卜素（维生素A原），E（α-生育酚）和C（抗坏血酸）用于癌症化学预防和治疗的实验，临床和流行病学研究。细胞和代谢效应取决于使用的剂量，暴露的持续时间和癌细胞类型。尽管最近的进展，抗癌机制仍然未知。关于维生素A、β-胡萝卜素、E和C在癌细胞生物学和代谢中的作用的研究对于它们在癌症治疗中的应用至关重要。放射自显影、超微结构和细胞表面研究表明，维生素A、E和C是癌细胞分化、细胞退化、膜生物发生、DNA、RNA、蛋白质和胶原合成以及癌前细胞转化为癌细胞的强调节因子。这些维生素发挥细胞毒性和细胞抑制作用，并可能逆转癌细胞的正常表型。维生素A、E和C与癌基因和生长因子的相互关系在癌细胞生物学中起着重要作用。本综述中的数据可以为了解抗癌机制提供新的见解，并为使用维生素A，E和C在癌症化学预防和治疗中提供理论基础。
Vitamins A (retinol, retinoids), beta-carotene (provitamin A), E (alpha-tocopherol), and C (ascorbic acid) are used in experimental, clinical and epidemiological studies for cancer chemoprevention and treatment. The cellular and metabolic effects are depending on the dose used, duration of exposure, and cancer cell type. Despite recent advances, the anticarcinogenic mechanisms remain as yet unknown. Studies regarding the role of vitamins A, beta-carotene, E and C in cancer cell biology and metabolism are of critical importance for their use in cancer treatment. Autoradiographic, ultrastructural and cell surface studies demonstrated that vitamins A, E and C are strong regulator factors of cancer cell differentiation, cell regression, membrane biogenesis, DNA, RNA, protein, and collagen synthesis, as well as transformation of precancer cells into cancer cells. These vitamins exert cytotoxic and cytostatic effects, and may reverse the cancer cell to the normal phenotype. Interrelation of vitamins A, E and C with oncogenes and growth factors play an important role in cancer cell biology. The data presented in this review can provide new insights for the understanding of anticarcinogenic mechanisms, and a rationale for the use of vitamins A, E and C in cancer chemo-prevention and treatment.