Clinical results of single-vessel versus multiple-vessel infrapopliteal intervention.

Clinical results of single-vessel versus multiple-vessel infrapopliteal intervention.
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单血管与多血管腘窝下介入治疗的临床结果。

DOI:
10.1016/j.jvs.2016.05.080
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发表时间:
2016
影响因子:
4.3
通讯作者:
Schermerhorn,MarcL
Schermerhorn,MarcL
中科院分区:
医学2区
文献类型:
--
作者:
Darling,JeremyD;McCallum,JohnC;Soden,PeterA;Hon,JohnJ;Guzman,RaulJ;Wyers,MarkC;Verhagen,HenceJ;Schermerhorn,MarcL

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同时进行血管内介入治疗对多条膝下血管的影响尚不清楚,此类手术的短期和长期后遗症尚未报道。方法从2004年至2014年,528例患者的673条肢体因组织缺损(77%),静息痛(13%),既往治疗血管狭窄(5%),急性肢体缺血(3%)或跛行(2%)。结局包括伤口愈合、RAS事件(再次介入、大截肢或狭窄[多普勒递增> 3.5倍])和死亡率。排除了没有严重肢体缺血(CLI)初始指征的患者。患者的特点是经历了一个单一的血管infropoplateal干预或多血管infropoplateal intervention.ResultsOf的673条肢体,558进行了成功的infropoplateal血管内介入CLI(86%的组织损失,14%的静息痛)。在单次手术中,503条肢体(90%)接受了单血管介入治疗,55条肢体(10%)接受了多血管介入治疗。接受单血管介入治疗的患者更常接受过同侧血管内手术(17% vs 6%;P= 0.03)或同侧旁路手术(20% vs 9%;P= 0.04)。Kaplan-Meier分析显示,229条肢体(49%)发生了1年内的RAS事件,1年内再次介入(22% vs 20%;P= 0.53)、大截肢(16% vs 10%;P= 0.24)或狭窄(29% vs 21%;P= 0.25)的发生率无显著差异。调整基线特征后,多变量回归分析表明,无论是大截肢率,也没有RAS事件之间的差异进行单血管与多血管介入(P= 0.26和P = 0.61,分别)。
ObjectiveThe effects of concomitant endovascular interventions on multiple infrapopliteal vessels are not well known, and the short-term and long-term sequelae of such procedures have not been reported.MethodsFrom 2004 to 2014, 673 limbs in 528 patients underwent an infrapopliteal endovascular intervention for tissue loss (77%), rest pain (13%), stenosis of a previously treated vessel (5%), acute limb ischemia (3%), or claudication (2%). Outcomes included wound healing, RAS events (reintervention, major amputation, or stenosis [>3.5x step-up by duplex]), and mortality. Patients without an initial indication of critical limb ischemia (CLI) were excluded. Patients were characterized as having undergone either a single-vessel infrapopliteal intervention or a multiple-vessel infrapopliteal intervention.ResultsOf the 673 limbs, 558 underwent a successful infrapopliteal endovascular intervention for CLI (86% for tissue loss, 14% for rest pain). During a single procedure, 503 limbs (90%) underwent a single-vessel intervention and 55 (10%) underwent a multiple-vessel intervention. Patients undergoing a single-vessel intervention more commonly underwent a prior ipsilateral endovascular procedure (17% vs 6%;P= .03) or a prior ipsilateral bypass procedure (20% vs 9%;P= .04). Kaplan-Meier analysis revealed that a RAS event ≤1 year occurred in 229 limbs (49%), with no significant difference in the 1-year rates of reintervention (22% vs 20%;P= .53), major amputation (16% vs 10%;P= .24), or stenosis (29% vs 21%;P= .25). After adjustment for baseline characteristics, multivariable regression illustrated that neither major amputation rates nor RAS events differed between patients undergoing a single-vessel vs a multiple-vessel intervention (P= .26 andP= .61, respectively).ConclusionsOur data suggest that a multiple-vessel intervention does not improve outcomes when compared to a single-vessel intervention following infrapopliteal angioplasty for CLI.
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