Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices-A Systematic Study.
Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices-A Systematic Study.
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DOI：
10.3390/polym13020292
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发表时间：
2021-01-18
期刊：
影响因子：
5
通讯作者：
Oschatz S
中科院分区：
文献类型：
--
作者：
Arbeiter D;Reske T;Teske M;Bajer D;Senz V;Schmitz KP;Grabow N;Oschatz S
在生物医学工程中，局部给药已变得不可或缺，支架是理想的载体平台。虽然在许多领域局部药物释放优于全身给药，但将药物掺入聚合物可能会影响所述基质的物理化学性质。这一点尤为重要，因为微创植入经常伴随着对植入物和涂层的机械应力。因此，将药物掺入聚合物可能会导致潜在的危及生命的植入物失效。我们使用热分析（差示扫描量热法，DSC）和拉伸试验研究了喷涂聚 - L - 乳酸（PLLA）/药物混合物，以确定所选药物，即西罗莫司、紫杉醇、地塞米松和环孢素A对聚合物物理化学性质的影响。对于所有药物以及PLLA/药物的比例，都观察到拉伸强度有所增加。对于西罗莫司和地塞米松，通过分别在200°C和240°C出现位移的药物熔融峰确定了PLLA/药物混合相系统，而紫杉醇和地塞米松导致了冷结晶。环孢素A不影响基质的热性能。总之，我们的数据有助于理解PLLA与不同药物之间的复杂相互作用。我们的结果对有针对性的热处理的必要性具有启示意义，以确保支架涂层的保质期和性能。
Local drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may influence the physico-chemical properties of said matrix. This is of particular relevance as minimally invasive implantation is frequently accompanied by mechanical stresses on the implant and coating. Thus, drug incorporation into polymers may result in a susceptibility to potentially life-threatening implant failure. We investigated spray-coated poly-l-lactide (PLLA)/drug blends using thermal measurements (DSC) and tensile tests to determine the influence of selected drugs, namely sirolimus, paclitaxel, dexamethasone, and cyclosporine A, on the physico-chemical properties of the polymer. For all drugs and PLLA/drug ratios, an increase in tensile strength was observed. As for sirolimus and dexamethasone, PLLA/drug mixed phase systems were identified by shifted drug melting peaks at 200 °C and 240 °C, respectively, whereas paclitaxel and dexamethasone led to cold crystallization. Cyclosporine A did not affect matrix thermal properties. Altogether, our data provide a contribution towards an understanding of the complex interaction between PLLA and different drugs. Our results hold implications regarding the necessity of target-oriented thermal treatment to ensure the shelf life and performance of stent coatings.
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影响因子：
2.2
作者：
Buenger, Carsten Michael;Grabow, Niels;Schareck, Wolfgang
通讯作者：
Schareck, Wolfgang
DOI：
10.1016/j.msec.2017.04.024
发表时间：
2017-09-01
影响因子：
7.9
作者：
Kim, Seong Min;Park, Sung-Bin;Han, Dong Keun
通讯作者：
Han, Dong Keun
影响因子：
2.3
作者：
Arbeiter, Daniela;Eickner, Thomas;Grabow, Niels
通讯作者：
Grabow, Niels
DOI：
10.1023/a:1013174400236
发表时间：
2001-01-01
期刊：
JOURNAL OF MATERIALS SCIENCE LETTERS
影响因子：
--
作者：
Freier, T;Kunze, C;Schmitz, KP
通讯作者：
Schmitz, KP
影响因子：
3
作者：
Darie-Nita, Raluca N.;Vasile, Cornelia;Rapa, Maria
通讯作者：
Rapa, Maria