Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells.
Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells.
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早期的BCR事件和B细胞上MHC II类上的抗原捕获，加工和加载。
DOI：
10.3389/fimmu.2014.00092
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发表时间：
2014
影响因子：
7.3
通讯作者：
Ploegh HL
中科院分区：
文献类型：
--
作者：
Avalos AM;Ploegh HL
B细胞是有效的抗原呈递细胞（APC），依赖于通过B细胞受体（BCR）的抗原摄取。抗原识别的机制仍然是一个争论的话题;虽然普遍的观点认为抗原需要是多价的BCR激活，单价抗原也可以启动B细胞应答。在这篇综述中，我们描述了所需的抗原摄取，加工和装载的肽到MHC II类车厢中的B细胞有效地介绍给CD 4 T细胞的步骤，特别是在BCR识别抗原的初始步骤。
B cells are efficient antigen-presenting cells (APCs), relying on antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review, we describe the steps required for antigen uptake, processing, and loading of peptides onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.