Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial
Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial
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DOI：
10.1007/s10856-010-4070-0
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发表时间：
2010-07-01
影响因子：
3.7
通讯作者：
Shen, Feng
中科院分区：
文献类型：
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作者：
Zhang, Erlin;Chen, Haiyan;Shen, Feng
通过与316L不锈钢和Mg-Mn-Zn镁合金的比较，研究了纯铁的生物腐蚀性能和血液与细胞的相容性，揭示了纯铁作为生物可降解材料的可能性。电化学和失重试验表明，纯铁在最初几天表现出相对较高的腐蚀速率，然后在随后的浸泡过程中由于表面上形成磷酸盐而降低到较低的水平。而纯铁的腐蚀并没有引起溶液pH值的显著升高。与316L和Mg-Mn-Zn合金相比，纯铁在中等腐蚀速率下具有生物降解性能。纯铁的动态凝血时间、凝血酶原时间和血浆凝固时间与316L和Mg-Mn-Zn合金相似，但溶血率和粘附血小板数密度明显低于316L和Mg-Mn-Zn合金。MTT结果显示，除25%24h提取物外，其余提取物均对细胞有毒性，且毒性随铁离子浓度的增加和作用时间的延长而增强。认为铁离子对细胞毒性的影响应有一个铁离子浓度阈值。
Biocorrosion properties and blood- and cell compatibility of pure iron were studied in comparison with 316L stainless steel and Mg-Mn-Zn magnesium alloy to reveal the possibility of pure iron as a biodegradable biomaterial. Both electrochemical and weight loss tests showed that pure iron showed a relatively high corrosion rate at the first several days and then decreased to a low level during the following immersion due to the formation of phosphates on the surface. However, the corrosion of pure iron did not cause significant increase in pH value to the solution. In comparison with 316L and Mg-Mn-Zn alloy, the pure iron exhibited biodegradable property in a moderate corrosion rate. Pure iron possessed similar dynamic blood clotting time, prothrombin time and plasma recalcification time to 316L and Mg-Mn-Zn alloy, but a lower hemolysis ratio and a significant lower number density of adhered platelets. MTT results revealed that the extract except the one with 25% 24 h extract actually displayed toxicity to cells and the toxicity increased with the increasing of the iron ion concentration and the incubation time. It was thought there should be an iron ion concentration threshold in the effect of iron ion on the cell toxicity.