Method of construction of a MRI-based tabular database of 3D stereotaxic co-ordinates for individual structures in the basal ganglia of Macaca mulatta
Method of construction of a MRI-based tabular database of 3D stereotaxic co-ordinates for individual structures in the basal ganglia of Macaca mulatta
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DOI：
10.1016/j.jneumeth.2005.05.016
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发表时间：
2005-12-15
影响因子：
3
通讯作者：
Subramanian, T
中科院分区：
文献类型：
--
作者：
Deogaonkar, M;Heers, M;Subramanian, T
灵长类动物模型通常用于帕金森病研究，以研究需要基底神经节结构精确定位的立体定位策略。我们展示了一种方法来构建一个广泛的表格数据库的3D立体定位坐标的各种基底神经节结构的高质量的磁共振（MR）图像的47只成年雌性3-5公斤恒河猴。对于每只动物，追踪基底神经节中的结构，因为它们出现在轴向MR图像上。将它们的最大轮廓投影在轴向平面中以创建图像堆叠，并计算每个结构的边缘的X、Y、Z坐标。这些坐标和单个核团的轮廓有助于描绘一个“共同区域”，该区域被进一步缩小到代表丘脑底核、苍白球、尾状核和两侧壳核中的“最可靠靶点”（MRTP）的点。公共区域和MRTP表示可以最明确地与结构相关联的区域，因此是给定结构的最明确目标。本研究的目的是展示构建方法，讨论这种表格数据库的可行性和有用性，可能会增加定位的准确性，同时使用基于图谱的立体定位。尽管MRI的使用仍然是一种标准做法，成像技术的进步使功能性手术的靶向更加准确，但在发展中国家，这意味着每次手术的成本过高。类似于这里描述的猴子数据库的基于群体的人类数据库，当与较便宜的成像模态一起使用时，沿着可以显著降低成本并增加靶向的准确性。(c)2005 Elsevier B. V.保留所有权利。
Primate models are commonly used in Parkinson's disease research to study stereotaxic strategies that demand accurate localization of the structures in basal ganglia. We demonstrate a method to construct an extensive tabular database of 3D stereotaxic co-ordinates of various basal ganglia structures from high-quality magnetic resonance (MR) images of 47 adult female 3-5 kg rhesus monkeys. For each animal, the structures in the basal ganglia were traced as they appeared on the axial MR images. Their maximal outlines were projected in the axial plane to create a stack of images and X, Y, Z co-ordinates were calculated for margins of each structure. These co-ordinates and the outlines of the individual nuclei help delineate a "common area," which was further narrowed down to a point that represents the 'most reliable target point' (MRTP) in subthalamic nucleus, globus pallidum, caudate and putamen on both sides. Common area and MRTP represent the region that can most definitely be associated with a structure and hence the most definite target for a given structure. The goal of this study is to demonstrate the method of construction, discuss the feasibility and usefulness of such a tabular database that could potentially add to accuracy of localization while using atlas-based stereotaxy. Though use of MRI remains a standard practice and advances in imaging have made targeting for functional surgery more accurate, in developing countries that implies prohibitive costs per procedure. Population based human databases similar to the monkey database described here, when used along with less expensive imaging modalities can reduce the costs considerably as well as add to the accuracy of targeting. (c) 2005 Elsevier B.V. All rights reserved.