Emergence and persistence of hantaviruses.
Emergence and persistence of hantaviruses.
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DOI：
10.1007/978-3-540-70962-6_10
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发表时间：
2007
影响因子：
--
通讯作者：
S. Klein;C. Calisher
中科院分区：
文献类型：
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作者：
S. Klein;C. Calisher
汉坦病毒疾病已经被认识了几百年，但直到1976年，它们还没有与感染因子相关。当Lee和同事分离出现在被称为汉坦病毒的病毒时，他们引入的技术允许进一步研究经典汉坦病毒疾病的病因，肾综合征出血热（HFRS），现在已知由多种汉坦病毒引起。汉坦病毒肺综合征（HPS）在新大陆的发现，以及它也可以由多种汉坦病毒（布尼亚病毒科，汉坦病毒属）中的任何一种引起，开启了对这些病毒的流行病学、病毒学、分子、行为和生态学研究的整个领域。似乎有一个单一的汉坦病毒-单一啮齿类宿主协会，因此，如果我们要降低人类感染汉坦病毒的风险，了解每种啮齿类宿主物种的特异性和影响它们的生态变量是至关重要的。
Hantaviral diseases have been recognized for hundreds of years but, until 1976, they had not been associated with an infectious agent. When Lee and colleagues isolated what is now known as Hantaan virus, the techniques they introduced allowed further investigations into the etiology of the classical hantavirus disease, hemorrhagic fever with renal syndrome (HFRS), now known to be caused by any of multiple hantaviruses. The discovery of hantavirus pulmonary syndrome (HPS) in the New World, and that it also can be caused by any of multiple hantaviruses (family Bunyaviridae, genus Hantavirus), has opened an entire field of epidemiologic, virologic, molecular, behavioral, and ecologic studies of these viruses. There appears to be a single hantavirus-single rodent host association, such that understanding the idiosyncrasies of each rodent host species and the ecologic variables that affect them are recognized as critical if we are to reduce human risk for