Puberty in female mice is not associated with increases in either body fat or leptin
Puberty in female mice is not associated with increases in either body fat or leptin
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DOI：
10.1210/en.142.11.4758
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发表时间：
2001-11-01
期刊：
影响因子：
4.8
通讯作者：
Bronson, FH
中科院分区：
文献类型：
--
作者：
Bronson, FH
据推测，青春期是触发时，身体脂肪，从而循环水平的瘦素超过临界阈值。四种实验在雌性小鼠中验证了这一假设。当年龄是自变量时，在青春期开始之前，体脂和瘦素的循环水平下降而不是增加。当生殖发育阶段是自变量时，无论是体脂还是循环中的瘦素水平都与青春期的开始相关。与此形成鲜明对比的是，生殖发育与体重密切相关。一个显着的夜间峰值循环水平的瘦素之前，在生殖发育的各个阶段，但最高水平后，而不是之前的第一个发情周期开始。通过改变女性的社会环境来加速或减缓青春期对体脂或瘦素都没有任何影响。在这些实验中，没有任何一个实验支持这样的假设，即体内脂肪的增加以及由此引起的瘦素循环水平的增加会触发雌性小鼠的青春期。
It has been hypothesized that puberty is triggered when body fat and hence circulating levels of leptin exceed critical thresholds. Four kinds of experiments tested that hypothesis in female mice. When age was the independent variable, body fat and circulating levels of leptin decreased rather than increased before the onset of puberty. When stage of reproductive development was the independent variable, neither body fat nor circulating levels of leptin correlated with the onset of puberty. In sharp contrast, reproductive development was well correlated with body weight. A significant nocturnal peak in circulating levels of leptin was seen before and at all stages of reproductive development, but the highest levels were seen after rather than before the first estrous cycle was initiated. Neither acceleration nor deceleration of puberty by varying the female's social environment had any effect on either body fat or leptin. There is no support in any of these experiments for the hypothesis that an increase in body fat and thus an increase in circulating levels of leptin triggers puberty in female mice.