Hepatitis B virus infection and decreased risk of stroke: a meta-analysis.
Hepatitis B virus infection and decreased risk of stroke: a meta-analysis.
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乙型肝炎病毒感染与中风风险降低：一项荟萃分析
DOI：
10.18632/oncotarget.19609
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发表时间：
2017-08-29
期刊：
影响因子：
--
通讯作者：
Xu K
中科院分区：
文献类型：
--
作者：
Wang Y;Xiong J;Chen X;Niu M;Chen X;Guan Y;Zheng K;Xu K
几项研究报告说，B肝炎病毒（HBV）感染可能会降低中风的风险。然而，它的关联是有争议的。因此，我们进行了系统回顾和荟萃分析，以调查B型肝炎病毒（HBV）感染与卒中风险之间的关系。通过检索PubMed、EMBASE和ISI Web of Science识别出2017年5月之前发表的相关研究。使用比值比（OR）/风险比（RR）值和相应的95%置信区间（CI）评估HBV感染与卒中风险之间的关系。我们使用DerSimonian和Laird提出的随机效应模型来量化这种关系。荟萃分析纳入了5篇文章，包括834，75例HBV感染患者和593，949例未感染对照。HBV感染患者发生卒中的风险显著低于未感染对照组（总体OR = 0.78; 95%CI = 0.70-0.86; I2 = 0%）。然而，这种负相关仅在队列研究中观察到（OR = 0.77; 95%CI = 0.69-0.86），而非横断面研究（OR = 1.10; 95%CI = 0.55-2.19）。总之，HBV感染与发生卒中的风险降低相关。
Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the corresponding 95% confidence intervals (CIs). We used the random effects model proposed by DerSimonian and Laird to quantify the relationship. Five articles, including 834,75 HBV-infected patients and 593,949 uninfected controls, were included in the meta-analysis. The risk of stroke was significantly lower in HBV-infected patients than in uninfected controls (summary OR = 0.78; 95% CI = 0.70–0.86; I2 = 0%). However, this inverse relationship was only observed in cohort studies (OR = 0.77; 95% CI = 0.69–0.86), rather than cross-sectional study (OR = 1.10; 95% CI = 0.55–2.19). In summary, HBV infection was associated with lower risk of developing stroke.