Single Nucleotide Polymorphisms and Haplotypes in Native American Populations
Single Nucleotide Polymorphisms and Haplotypes in Native American Populations
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DOI：
10.1002/ajpa.21560
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Kidd, Kenneth K.
中科院分区：
文献类型：
--
作者：
Kidd, Judith R.;Friedlaender, Francoise;Kidd, Kenneth K.
常染色体DNA多态性可以提供新的信息和理解起源和现代美洲原住民人口之间的关系。与此同时，常染色体标记可以提供大量信息，它们在选择使用的标记时也容易受到确定偏差的影响。识别可用于推断美洲原住民祖先的标记可被视为与识别进一步探索历史的标记分开。在目前的研究中，我们使用了9个美洲原住民群体的数据，将基于大型单倍型数据集的结果与相对较小的独立单核苷酸多态性集进行比较。我们感兴趣的是，单个实验室可能能够收集的有限数据集类型最适合解决两个不同的感兴趣的问题。首先，我们能在多大程度上区分美洲原住民群体和/或通过将个体分配到其原始群体来推断其祖先？第二，我们能在多大程度上推断出美洲原住民和他们的欧亚起源之间的历史/进化关系？我们的结论是，只有涉及多个人群的多个常染色体标记的大型综合数据集才能回答这两个问题；不同的小组标记只能回答其中一个问题。利用我们最大的数据集，我们看到，除了玛雅人和盖丘亚人样本之间无法解释的密切关系外，新世界从北到南与旧世界人口的距离普遍增加。[J] .中国生物医学工程学报，2011。(C) 2011 Wiley期刊公司
Autosomal DNA polymorphisms can provide new information and understanding of both the origins of and relationships among modern Native American populations. At the same time that autosomal markers can be highly informative, they are also susceptible to ascertainment biases in the selection of the markers to use. Identifying markers that can be used for ancestry inference among Native American populations can be considered separate from identifying markers to further the quest for history. In the current study, we are using data on nine Native American populations to compare the results based on a large haplotype-based dataset with relatively small independent sets of single nucleotide polymorphisms. We are interested in what types of limited datasets an individual laboratory might be able to collect are best for addressing two different questions of interest. First, how well can we differentiate the Native American populations and/or infer ancestry by assigning an individual to her population(s) of origin? Second, how well can we infer the historical/evolutionary relationships among Native American populations and their Eurasian origins? We conclude that only a large comprehensive dataset involving multiple autosomal markers on multiple populations will be able to answer both questions; different small sets of markers are able to answer only one or the other of these questions. Using our largest dataset, we see a general increasing distance from Old World populations from North to South in the New World except for an unexplained close relationship between our Maya and Quechua samples. Am J Phys Anthropol 146:495-502, 2011. (C) 2011 Wiley Periodicals, Inc.