Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States-September-October 2009
Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States-September-October 2009
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DOI：
10.1093/cid/ciq021
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发表时间：
2011-01-01
影响因子：
11.8
通讯作者：
Finelli, Lyn
中科院分区：
文献类型：
--
作者：
Skarbinski, Jacek;Jain, Seema;Finelli, Lyn
鉴于2009年春季至秋季2009年大流行甲型H1N1流感病毒(pH1N1)感染的临床严重程度可能会恶化，我们对2009年9月至10月期间因pH1N1感染住院的患者进行了临床病例系列。病例患者被定义为通过实时逆转录聚合酶链反应检测结果呈pH1N1病毒阳性的住院患者。在255名住院患者中，34%住进重症监护室，8%死亡。 34% 的患者是 18 岁以下的儿童，8% 是 65 岁以上的成人，67% 的患者有基础疾病。 255 名患者中有 103 名 (46%) 入院时拍摄的胸部 X 光片显示出与肺炎相符的结果。在 255 名住院患者中，208 名（82%）接受了神经氨酸酶抑制剂治疗，但只有 47% 的患者在发病后 2 天以内开始治疗。总体而言，2009 年秋季住院的 pH1N1 感染患者的特征与 2009 年春季住院的 pH1N1 感染患者的特征相似，这表明在此期间临床严重程度没有显着变化。
Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children < 18 years of age, 8% were adults >= 65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started < 2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.