Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials
Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials
复制标题
类金刚石碳改性表面释放抗菌金属离子用于新型多功能植入材料
DOI：
10.1557/jmr.2016.275
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发表时间：
2016-09-14
影响因子：
2.7
通讯作者：
Westerhausen, Christoph
中科院分区：
文献类型：
--
作者：
Buchegger, Sascha;Vogel, Caroline;Westerhausen, Christoph
这项研究的目的是合成具有内置时间相关抗菌性能的硬而低磨损的新型植入材料，这种材料可以通过明确的时间依赖和有限的金属离子释放来定制。我们能够利用ECR(电子回旋共振)等离子体在典型的钛植入材料上合成这样的智能植入表面，方法是将聚合物薄膜转化为类金刚石碳(DLC)，其中包含金属纳米颗粒作为受控金属离子释放的储存库。我们发现，抗菌金属离子的释放量是时间的双指数函数，在最初的几个小时内具有较高的释放率，随后几天内离子释放率下降。为了描述我们的实验结果，我们建立了一个动力学模型，假设表面附近的纳米颗粒和DLC体内的纳米颗粒都对释放的离子总量有贡献，但释放的时间常数不同。
The aim of this study was the synthesis of hard and low-abrasive novel implant materials with built-in time-dependent antibacterial properties, which can be tailored by a well-defined time-dependent and finite release of metal ions. We were able to synthesize such smart implant surfaces employing ECR (electron cyclotron resonance)-plasma on typical titanium implant material by transforming a polymer film into diamond-like carbon (DLC) which contains metal nanoparticles as reservoirs for controlled metal ion release. We found that the amount of released antibacterial metal ions is a biexponential function of time with a high release rate during the first few hours followed by a decreased ion release rate within the following days. To describe our experimental findings, we developed a kinetic model assuming that both nanoparticles near the surface and nanoparticles in the DLC bulk contribute to the total amount of ions released with different time constants.