Association of amygdala volumes with cortisol secretion in unipolar depressed patients
Association of amygdala volumes with cortisol secretion in unipolar depressed patients
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DOI：
10.1016/j.pscychresns.2011.09.007
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发表时间：
2012-05-31
影响因子：
2.3
通讯作者：
Zobel, Astrid
中科院分区：
文献类型：
--
作者：
Schuhmacher, Anna;Moessner, Rainald;Zobel, Astrid
重度抑郁症（MDD）伴随着大脑结构的形态变化，这些结构对于介导抑郁的神经回路（如海马体和杏仁核）非常重要。在抑郁症期间经常可以观察到下丘脑-垂体-肾上腺皮质（HPA）系统的过度活跃，导致糖皮质激素分泌增加，并且被认为在诱导这些形态变化中发挥着重要作用。我们使用磁共振成像来研究 86 名单相抑郁症住院患者和 87 名健康对照者的杏仁核和海马体积的变化，然后将 76 名住院患者的杏仁核和海马体积与基线和短期抗抑郁治疗期间地塞米松/促肾上腺皮质激素释放激素 (Dex/CRH) 测试中皮质醇分泌曲线下面积相关联。根据最近发表的研究，首次抑郁发作患者的左右杏仁核体积均小于健康对照者。复发性抑郁症患者的海马体积减少，而杏仁核体积正常。在对复发性抑郁发作的患者进行抗抑郁治疗期间，左右杏仁核体积越大，HPA 活性的降低就越明显，HPA 活性的降低是通过 DEX/CRH 联合测试中的皮质醇分泌来测量的。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Major depressive disorder (MDD) is accompanied by morphological changes of brain structures which are of great importance in the neural circuitry mediating depression like the hippocampus and the amygdala. Hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system resulting in enhanced glucocorticoid secretion can often be observed during depression and has been thought to play an important role in inducing these morphological changes. We used magnetic resonance imaging to investigate alterations of amygdala and hippocampal volumes in 86 in-patients with unipolar depression and 87 healthy controls, and we then correlated amygdala and hippocampal volumes of 76 in-patients with the area under the curve of cortisol secretion in the dexamethasone/corticotropin releasing hormone (Dex/CRH) test at baseline and during short-term antidepressant therapy. In line with recently published studies both left and right amygdala volumes of patients in a first depressive episode were smaller than those of healthy controls. Patients with recurrent depressive episodes showed a reduction of hippocampal volumes, while amygdala volumes were normal. Larger left and right amygdala volumes correlated with a more pronounced reduction of HPA activity, measured by the cortisol secretion in the combined DEX/CRH test, during antidepressant therapy in patients with recurrent depressive episodes. (C) 2011 Elsevier Ireland Ltd. All rights reserved.