The enigma of IgE+ B-cell memory in human subjects
The enigma of IgE+ B-cell memory in human subjects
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DOI：
10.1016/j.jaci.2012.12.1569
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发表时间：
2013-04-01
影响因子：
14.2
通讯作者：
Aalberse, Rob C.
中科院分区：
文献类型：
--
作者：
Davies, Janet M.;Platts-Mills, Thomas A.;Aalberse, Rob C.
通过对小鼠模型的研究，我们对ige开关B细胞的起源和命运的理解得到了显著提高。ige开关B细胞的直接前体要么是相对幼稚的未开关B细胞，要么是成熟的igg开关B细胞。这两种途径分别称为直接途径和间接途径。每种途径产生的IgE反应差异很大，这在很大程度上反映了在生发中心度过的时间的差异，从而反映了克隆扩增、体细胞超突变、亲和成熟和获得记忆表型的时间的差异。人类受试者的IgE反应的临床和治疗意义仍然存在争议，主要是因为动物模型中使用的免疫程序与经典的对花粉和螨虫过敏原的特应性致敏有很大不同。根据现有的有限信息，这些特应性IgE反应似乎具有相对较低的IgG/IgE比率、较低的b细胞记忆和适度的亲和力成熟，这与直接转换途径非常吻合。目前还不清楚IgE反应是如何演变成覆盖广泛的表位库的，包括每个过敏原的许多表位，以及来自单一过敏原来源的许多不同的过敏原。[J] .中华变态反应杂志，2013;31:972-6。
Our understanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in mouse models. The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched B cell or a mature IgG-switched B cell. These 2 routes are referred to as the direct and indirect pathways, respectively. IgE responses derived from each pathway differ significantly, largely reflecting the difference in time spent in a germinal center and thus time for clonal expansion, somatic hypermutation, affinity maturation, and acquisition of a memory phenotype. The clinical and therapeutic implications for IgE responses in human subjects are still a matter of debate, largely because the immunization procedures used in the animal models are significantly different from classical atopic sensitization to allergens from pollen and mites. On the basis of the limited information available, it seems likely that these atopic IgE responses are characterized by a relatively low IgG/IgE ratio, low B-cell memory, and modest affinity maturation, which fits well with the direct switching pathway. It is still unresolved how the IgE response evolves to cover a wide epitope repertoire involving many epitopes per allergen, as well as many different allergens from a single allergen source. (J Allergy Clin Immunol 2013; 131: 972-6.)