MicroRNA in cancer: new hopes for antineoplastic chemotherapy.
MicroRNA in cancer: new hopes for antineoplastic chemotherapy.
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DOI：
10.3109/03009734.2012.660551
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发表时间：
2012-05
影响因子：
3.4
通讯作者：
Croce CM
中科院分区：
文献类型：
--
作者：
Di Leva G;Briskin D;Croce CM
microRNA（miRNAs）是一类在进化上保守的、广泛分布于物种间的内源性非编码小RNA。它们的主要功能是负调节mRNA靶基因，并且已经发现miRNA表达在所有人类癌症中被解除调节，其中miRNA在肿瘤发生中起关键作用，作为肿瘤抑制因子或作为癌基因起作用。本文综述了miRNA与肿瘤的关系，包括miRNA在肿瘤发生、生长、侵袭和转移中的作用。我们还将重点介绍miRNAs的应用为未来潜在的miRNAs疗法的发展奠定基础的文献。
MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that are evolutionarily conserved and widely distributed among species. Their major function is to negatively regulate mRNA target genes, and miRNA expression has been found to be deregulated in all human cancers, where miRNAs play critical roles in tumorigenesis, functioning either as tumor suppressors or as oncogenes. This review provides a current overview of the connection between miRNAs and cancer by covering the recent advances in miRNA involvement in human cancer including initiation, growth, invasion, and metastasis. We will also highlight the literature where application of miRNAs has created the foundation for the development of potential future miRNA therapy.