Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
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DOI：
10.1016/s0027-5107(99)00232-8
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发表时间：
2000-03-17
影响因子：
2.3
通讯作者：
Gonzalez, FJ
中科院分区：
文献类型：
--
作者：
Corton, JC;Lapinskas, PJ;Gonzalez, FJ
过氧化物酶体增殖体（PP）是一类结构不同的化学物质。这些化学物质对啮齿动物和人类有不同的作用，包括调节脂质代谢、促进生长和诱导肝癌的发生。大多数（如果不是全部的话）PP的作用是由核受体超家族的三个成员介导的，称为PP活化受体（PPAR）。在这篇综述中，我们讨论了PPAR α，肝脏中主要的PPAR参与PP促进生长和肝癌作用的证据。(C) 2000 Elsevier Science B.V.版权所有。
Peroxisome proliferators (PP) are a large class of structurally dissimilar chemicals. These chemicals have diverse effects in rodents and humans, including regulation of lipid metabolism, growth promotion, and induction of hepatocarcinogenesis. Most, if not all, effects of PP are mediated by three members of the nuclear receptor superfamily called PP-activated receptors (PPAR). In this review, we discuss the evidence that PPAR alpha, the predominant PPAR in the, liver is involved in the growth promoting and hepatocarcinogenic effects of PP. (C) 2000 Elsevier Science B.V. All rights reserved.