Functional divergence in protein (family) sequence evolution
Functional divergence in protein (family) sequence evolution
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DOI：
10.1023/a:1024197424306
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发表时间：
2003-07-01
期刊：
影响因子：
1.5
通讯作者：
Gu, X
中科院分区：
文献类型：
--
作者：
Gu, X
正如今天广泛用于推断“功能”一样，同源性搜索基于中性理论，即功能意义最大的位点处于最强的选择约束和最低的进化速率下，反之亦然。因此，位点特异性速率变化（或改变的选择约束）与蛋白质（家族）进化过程中的功能分化有关。本文就这方面的研究进展作一综述。我们展示了大量的功能信息可以从进化的角度获得，这反过来又可以用来促进高通量的功能分析。还指出了进化功能基因组学的出现。相关软件DIVERGE可从http://xgu1.zool.iastate.edu获取。
As widely used today to infer 'function', the homology search is based on the neutral theory that sites of greatest functional significance are under the strongest selective constraints as well as lowest evolutionary rates, and vice versa. Therefore, site-specific rate changes ( or altered selective constraints) are related to functional divergence during protein ( family) evolution. In this paper, we review our recent work about this issue. We show a great deal of functional information can be obtained from the evolutionary perspective, which can in turn be used to facilitate high throughput functional assays. The emergence of evolutionary functional genomics is also indicated. The related software DIVERGE can be obtained form http://xgu1.zool.iastate.edu.