Upregulation of microRNA-450 inhibits the progression of lung cancer in vitro and in vivo by targeting interferon regulatory factor 2
Upregulation of microRNA-450 inhibits the progression of lung cancer in vitro and in vivo by targeting interferon regulatory factor 2
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DOI：
10.3892/ijmm.2016.2612
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发表时间：
2016-07-01
影响因子：
5.4
通讯作者：
Lin, Qiang
中科院分区：
文献类型：
--
作者：
Liu, Fabing;Yu, Xiaobo;Lin, Qiang
MicroRNAs (miRNAs) are a class of non-coding RNAs that play pivotal roles in human lung cancer development. The majority of studies have focused on either non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC). In the present study, we investigated a plausible mechanism of action of miR-450 in these types of lung cancer. We found that the level of miR-450 was decreased in lung cancer cell lines, as well as in solid tumors. As exemplified in the H510A (SCLC) and H2291 (NSCLC) cells, transfection with lentivirus carrying miR-450 upregulated miR-450 expression and significantly attenuated lung cancer cell proliferation and invasion, as well as the growth of implantated tumors. Interferon regulatory factor 2 (IRF2) was also verified to be a direct target of miR-450 in lung cancer cells. The overexpression of IRF2 in the H510A and H2291 cells abrogated the inhibitory effects of miR-450 on lung cancer cell proliferation and invasion. Taken together, in this study, we identified a novel role of miR-450 in lung cancer. miR-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.
