Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): a large population-based Internet survey in Japan.
Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): a large population-based Internet survey in Japan.
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DOI：
10.1186/s13030-016-0070-8
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发表时间：
2016
影响因子：
2.1
通讯作者：
Fukudo S
中科院分区：
文献类型：
--
作者：
Kanazawa M;Miwa H;Nakagawa A;Kosako M;Akiho H;Fukudo S
腹胀是肠易激综合征伴便秘（IBS-C）患者的常见症状。然而，在IBS的罗马III诊断标准中，它并不包括在必需的项目中。关于IBS-C患者腹部腹胀的影响知之甚少。本研究的目的是使用一个大的基于人群的样本，调查什么是IBS-C受试者中最令人烦恼的症状。对来自日本各地普通公众的30，000名成年人进行了互联网调查，以使用罗马III诊断问卷识别IBS亚型。因此，筛选的IBS-C受试者和随机选择的相同数量的年龄和性别匹配的非IBS受试者作为对照，被要求回答一份关于他们在日常生活中经历的焦虑程度、对排便习惯的想法、他们的主要胃肠道症状以及加重因素（仅针对IBS-C）的问卷。筛查调查显示，总体IBS患病率为16.5%（女性17.4%，男性15.5%），其中2.8%符合IBS-C标准，4.5%符合IBS伴腹泻（IBS-D）标准，8.2%符合混合型IBS（IBS-M）标准。835例IBS-C受试者中的759例（90.9%）和830例对照受试者中的746例（89.9%）完成了连续问卷。IBS-C受试者在日常生活中感到更高程度的焦虑（p < 0.01），并认为排便习惯是健康的指标（p < 0.01），在更大程度上比对照组受试者。在IBS-C中，焦虑程度与腹部不适（p < 0.01）、疼痛（p < 0.01）和腹胀（p = 0.02）显著相关，但与排便习惯的频率无关（p > 0.1）。腹胀是最令人烦恼的症状（27.5%），更容易发生在饭后（52.2%），工作/学校（29.2%）和压力期间（26.8%）。只有4.5%的IBS-C受试者报告腹痛为“最令人烦恼”的症状。一项基于人群的大型互联网调查表明，腹胀对诊断为IBS-C的受试者的日常生活有很大影响。IBS-C患者不仅要评估排便/腹痛，还要评估腹胀。本文的在线版本（doi：10.1186/s13030-016-0070-8）包含补充材料，可供授权用户使用。
Abdominal bloating is a common symptom in patients with irritable bowel syndrome with constipation (IBS-C). However, it is not included among the required items in the Rome III diagnostic criteria for IBS. Little is known about an impact of abdominal bloating seen in patients with IBS-C. Using a large population-based sample, the aim of the present study was to investigate what is the most bothersome symptom in subjects with IBS-C. An Internet survey of 30,000 adults drawn from the general public throughout Japan was conducted to identify subtypes of IBS using the Rome III diagnostic questionnaire. Consecutively, the screened subjects with IBS-C and the same number of age- and sex-matched non-IBS subjects who were randomly selected as controls were asked to answer a questionnaire on the degree of anxiety they experienced in their daily lives, thoughts about bowel habit, and their dominant gastrointestinal symptoms together with exacerbation factors (for IBS-C only). The screening survey showed that the prevalence of overall IBS was 16.5 % (female 17.4 %, male 15.5 %) and that 2.8 % met the criteria for IBS-C, 4.5 % for IBS with diarrhea (IBS-D) and 8.2 % for mixed IBS (IBS-M). Seven hundred and fifty-nine of 835 (90.9 %) subjects with IBS-C and 746 of 830 (89.9 %) control subjects completed the consecutive questionnaire. IBS-C subjects felt a higher degree of anxiety in their daily lives (p < 0.01) and considered bowel habit to be an indicator of health (p < 0.01) to a greater extent than control subjects. In IBS-C, the degree of anxiety was significantly associated with abdominal discomfort (p < 0.01), pain (p < 0.01) and bloating (p = 0.02), but not with the frequency of bowel habit (p > 0.1). Abdominal bloating was the most bothersome symptom (27.5 %), which was more likely to occur after a meal (52.2 %), at work/school (29.2 %) and during times of stress (26.8 %). Only 4.5 % of IBS-C subjects reported abdominal pain as the ‘most bothersome’ symptom. A large population-based Internet survey suggests that abdominal bloating has a great impact on the daily lives of subjects diagnosed with IBS-C. Not only bowel movement/abdominal pain but also abdominal bloating should be evaluated in patients with IBS-C. The online version of this article (doi:10.1186/s13030-016-0070-8) contains supplementary material, which is available to authorized users.