THE DOUBLY ADAPTIVE BIASED COIN DESIGN FOR SEQUENTIAL CLINICAL-TRIALS
THE DOUBLY ADAPTIVE BIASED COIN DESIGN FOR SEQUENTIAL CLINICAL-TRIALS
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DOI：
10.1016/0378-3758(94)90038-8
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发表时间：
1994-02-01
影响因子：
0.9
通讯作者：
EISELE, JR
中科院分区：
文献类型：
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作者：
EISELE, JR
在临床试验中，当期望的分配比例未知时，提出了一种偏向硬币设计，用于将受试者分配到治疗A和B。该设计是双重适应性的，因为它考虑到分配给每个治疗的受试者的比例和所需分配比例的当前估计。当受试者的反应是来自标准指数族的独立随机变量时，建立了受试者被分配到治疗中的比例的强大数定律。正常情况是以应用程序的形式呈现的。
A biased coin design is proposed for the allocation of subjects to treatments A and B in a clinical trial when the desired allocation proportions are unknown. The design is doubly adaptive in the sense that it takes account of the proportion of subjects assigned to each treatment and the current estimate of the desired allocation proportion. A strong law of large numbers is established for the proportion of subjects assigned to a treatment when subject responses are independent random variables from standard exponential families. The normal case is presented as an application.