On designing experiments for a dynamic response modeled by regression splines

On designing experiments for a dynamic response modeled by regression splines
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关于设计由回归样条建模的动态响应的实验

DOI:
10.1002/asmb.2490
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发表时间:
2020
影响因子:
1.4
通讯作者:
Saleh, Moein
Saleh, Moein
中科院分区:
数学4区
文献类型:
--
作者:
Pan, Rong;Saleh, Moein

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动态响应系统在科学、工程和医学应用中经常被发现,但在文献中对此类系统的实验设计的讨论相对较少。对于实验者来说,设计这样的实验需要决定(1)何时或在何处沿着动态变量进行响应测量,以及(2)如何选择实验因素及其水平的组合。第一个考虑因素对于这样的实验是独特的,特别是当测量成本很高时。在本文中,我们提出了一种设计方法,通过混合效应的线性模型,这是基于一个层次的B-样条函数的动态响应。我们开发了几个定理,可以帮助找到一个统计上有效的抽样计划,并提出了一个算法,搜索动态响应系统的D-最优设计。
Dynamic response systems are often found in science, engineering, and medical applications, but the discussion on experimental design for such a system is relatively rare in literature. For an experimenter, designing such experiments requires making decisions on (1) when or where to take response measurements along the dynamic variable and (2) how to choose the combination of experimental factors and their levels. The first consideration is unique for such experiments, especially when the measurement cost is high. In this paper, we present a design approach through the mixed‐effect linear model, which is based on a hierarchical B‐spline function for the dynamic response. We develop several theorems that can assist in finding a statistically efficient sampling plan and propose an algorithm for searching the D‐optimal design of a dynamic response system.
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